PittsburghV1, Main, Exploration, bibRecord, 000991

Upregulation of NHE1 protein expression enables glioblastoma cells to escape TMZ-mediated toxicity via increased H+ extrusion, cell migration and survival

Identifieur interne : 000991 ( Main/Exploration ); précédent : 000990; suivant : 000992

Upregulation of NHE1 protein expression enables glioblastoma cells to escape TMZ-mediated toxicity via increased H+ extrusion, cell migration and survival

Auteurs : Damin Cong [République populaire de Chine, États-Unis] ; Wen Zhu [États-Unis] ; Yejie Shi [États-Unis] ; Kelli B. Pointer [États-Unis] ; Paul A. Clark [États-Unis] ; Hongmei Shen [États-Unis] ; John S. Kuo [États-Unis] ; Shaoshan Hu [République populaire de Chine] ; Dandan Sun [République populaire de Chine, États-Unis]

Source :

Carcinogenesis [ 0143-3334 ] ; 2014.

RBID : PMC:4146414

Descripteurs français

English descriptors

KwdEn :
- Acid-Base Equilibrium, Animals, Antineoplastic Agents, Alkylating (pharmacology), Apoptosis, Astrocytes (metabolism), Biological Transport, Cation Transport Proteins (genetics), Cation Transport Proteins (metabolism), Cell Line, Tumor, Cell Movement, Cell Survival, Dacarbazine (analogs & derivatives), Dacarbazine (pharmacology), Drug Resistance, Neoplasm, Enzyme Activation, Extracellular Signal-Regulated MAP Kinases (metabolism), Gene Expression Regulation, Neoplastic (drug effects), Glioblastoma, Humans, MAP Kinase Signaling System, Mice, Neural Stem Cells (metabolism), Sodium-Hydrogen Antiporter (genetics), Sodium-Hydrogen Antiporter (metabolism), Up-Regulation.
MESH :
- chemical , analogs & derivatives : Dacarbazine.
- chemical , genetics : Cation Transport Proteins, Sodium-Hydrogen Antiporter.
- chemical , metabolism : Cation Transport Proteins, Extracellular Signal-Regulated MAP Kinases, Sodium-Hydrogen Antiporter.
- chemical , pharmacology : Antineoplastic Agents, Alkylating, Dacarbazine.
- drug effects : Gene Expression Regulation, Neoplastic.
- metabolism : Astrocytes, Neural Stem Cells.
- Acid-Base Equilibrium, Animals, Apoptosis, Biological Transport, Cell Line, Tumor, Cell Movement, Cell Survival, Drug Resistance, Neoplasm, Enzyme Activation, Glioblastoma, Humans, MAP Kinase Signaling System, Mice, Up-Regulation.

Abstract

Summary

Sodium–hydrogen exchanger isoform 1 (NHE1) plays a role in survival and migration/invasion of several cancers and emerges as a new therapeutic target. In this study, we investigated roles of NHE1 in glioma cells in counteracting chemo reagent temozolomide.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146414

DOI: 10.1093/carcin/bgu089
PubMed: 24717311
PubMed Central: 4146414

Affiliations:

République populaire de Chine, États-Unis

Le document en format XML

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 extrusion, cell migration and survival</title>
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 extrusion, cell migration and survival</title>
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<author><name sortKey="Kuo, John S" sort="Kuo, John S" uniqKey="Kuo J" first="John S." last="Kuo">John S. Kuo</name>
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<country xml:lang="fr">États-Unis</country>
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<term>Animals</term>
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<term>Apoptosis</term>
<term>Astrocytes (metabolism)</term>
<term>Biological Transport</term>
<term>Cation Transport Proteins (genetics)</term>
<term>Cation Transport Proteins (metabolism)</term>
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<term>Cell Survival</term>
<term>Dacarbazine (analogs & derivatives)</term>
<term>Dacarbazine (pharmacology)</term>
<term>Drug Resistance, Neoplasm</term>
<term>Enzyme Activation</term>
<term>Extracellular Signal-Regulated MAP Kinases (metabolism)</term>
<term>Gene Expression Regulation, Neoplastic (drug effects)</term>
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<term>MAP Kinase Signaling System</term>
<term>Mice</term>
<term>Neural Stem Cells (metabolism)</term>
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<term>Sodium-Hydrogen Antiporter (metabolism)</term>
<term>Up-Regulation</term>
</keywords>
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<term>Antinéoplasiques alcoylants (pharmacologie)</term>
<term>Antiport des ions sodium-hydrogène (génétique)</term>
<term>Antiport des ions sodium-hydrogène (métabolisme)</term>
<term>Apoptose</term>
<term>Astrocytes (métabolisme)</term>
<term>Cellules souches neurales (métabolisme)</term>
<term>Dacarbazine (analogues et dérivés)</term>
<term>Dacarbazine (pharmacologie)</term>
<term>Extracellular Signal-Regulated MAP Kinases (métabolisme)</term>
<term>Glioblastome</term>
<term>Humains</term>
<term>Lignée cellulaire tumorale</term>
<term>Mouvement cellulaire</term>
<term>Régulation de l'expression des gènes tumoraux ()</term>
<term>Régulation positive</term>
<term>Résistance aux médicaments antinéoplasiques</term>
<term>Souris</term>
<term>Survie cellulaire</term>
<term>Système de signalisation des MAP kinases</term>
<term>Transport biologique</term>
<term>Transporteurs de cations (génétique)</term>
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<term>Sodium-Hydrogen Antiporter</term>
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<term>Extracellular Signal-Regulated MAP Kinases</term>
<term>Sodium-Hydrogen Antiporter</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antineoplastic Agents, Alkylating</term>
<term>Dacarbazine</term>
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<keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Dacarbazine</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Gene Expression Regulation, Neoplastic</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Antiport des ions sodium-hydrogène</term>
<term>Transporteurs de cations</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Astrocytes</term>
<term>Neural Stem Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Antiport des ions sodium-hydrogène</term>
<term>Astrocytes</term>
<term>Cellules souches neurales</term>
<term>Extracellular Signal-Regulated MAP Kinases</term>
<term>Transporteurs de cations</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antinéoplasiques alcoylants</term>
<term>Dacarbazine</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Acid-Base Equilibrium</term>
<term>Animals</term>
<term>Apoptosis</term>
<term>Biological Transport</term>
<term>Cell Line, Tumor</term>
<term>Cell Movement</term>
<term>Cell Survival</term>
<term>Drug Resistance, Neoplasm</term>
<term>Enzyme Activation</term>
<term>Glioblastoma</term>
<term>Humans</term>
<term>MAP Kinase Signaling System</term>
<term>Mice</term>
<term>Up-Regulation</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Activation enzymatique</term>
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<term>Apoptose</term>
<term>Glioblastome</term>
<term>Humains</term>
<term>Lignée cellulaire tumorale</term>
<term>Mouvement cellulaire</term>
<term>Régulation de l'expression des gènes tumoraux</term>
<term>Régulation positive</term>
<term>Résistance aux médicaments antinéoplasiques</term>
<term>Souris</term>
<term>Survie cellulaire</term>
<term>Système de signalisation des MAP kinases</term>
<term>Transport biologique</term>
<term>Équilibre acidobasique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>Summary</title>
<p>Sodium–hydrogen exchanger isoform 1 (NHE1) plays a role in survival and migration/invasion of several cancers and emerges as a new therapeutic target. In this study, we investigated roles of NHE1 in glioma cells in counteracting chemo reagent temozolomide.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
<li>États-Unis</li>
</country>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Cong, Damin" sort="Cong, Damin" uniqKey="Cong D" first="Damin" last="Cong">Damin Cong</name>
</noRegion>
<name sortKey="Hu, Shaoshan" sort="Hu, Shaoshan" uniqKey="Hu S" first="Shaoshan" last="Hu">Shaoshan Hu</name>
<name sortKey="Sun, Dandan" sort="Sun, Dandan" uniqKey="Sun D" first="Dandan" last="Sun">Dandan Sun</name>
</country>
<country name="États-Unis"><noRegion><name sortKey="Cong, Damin" sort="Cong, Damin" uniqKey="Cong D" first="Damin" last="Cong">Damin Cong</name>
</noRegion>
<name sortKey="Clark, Paul A" sort="Clark, Paul A" uniqKey="Clark P" first="Paul A." last="Clark">Paul A. Clark</name>
<name sortKey="Kuo, John S" sort="Kuo, John S" uniqKey="Kuo J" first="John S." last="Kuo">John S. Kuo</name>
<name sortKey="Kuo, John S" sort="Kuo, John S" uniqKey="Kuo J" first="John S." last="Kuo">John S. Kuo</name>
<name sortKey="Pointer, Kelli B" sort="Pointer, Kelli B" uniqKey="Pointer K" first="Kelli B." last="Pointer">Kelli B. Pointer</name>
<name sortKey="Shen, Hongmei" sort="Shen, Hongmei" uniqKey="Shen H" first="Hongmei" last="Shen">Hongmei Shen</name>
<name sortKey="Shi, Yejie" sort="Shi, Yejie" uniqKey="Shi Y" first="Yejie" last="Shi">Yejie Shi</name>
<name sortKey="Sun, Dandan" sort="Sun, Dandan" uniqKey="Sun D" first="Dandan" last="Sun">Dandan Sun</name>
<name sortKey="Sun, Dandan" sort="Sun, Dandan" uniqKey="Sun D" first="Dandan" last="Sun">Dandan Sun</name>
<name sortKey="Zhu, Wen" sort="Zhu, Wen" uniqKey="Zhu W" first="Wen" last="Zhu">Wen Zhu</name>
</country>
</tree>
</affiliations>
</record>

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Upregulation of NHE1 protein expression enables glioblastoma cells to escape TMZ-mediated toxicity via increased H+ extrusion, cell migration and survival

Upregulation of NHE1 protein expression enables glioblastoma cells to escape TMZ-mediated toxicity via increased H+ extrusion, cell migration and survival

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